解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Human papillomavirus (HPV) vaccines protect against infections with the most oncogenic HPV types, cervical intraepithelial neoplasia (CIN) and cervical cancer. We investigated whether development of cervical intraepithelial neoplasia (CIN) lesions in HPV-vaccinated women is associated with vaccine-targeted HPV types o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32848
更新日期:2020-05-01 00:00:00
abstract::Smoking is indisputably linked to lung cancer, yet only a small fraction of smokers develops this disease. Although previously tobacco-derived carcinogens and enzyme polymorphisms have been identified to increase the risk for smokers, recent epidemiological data suggest even sex-specificity as a new and additional fac...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.32716
更新日期:2020-05-01 00:00:00
abstract::In this registry-based cohort study, we estimated the risk of human papillomavirus (HPV)-related anogenital premalignancies and cancer in renal transplant recipients (RTRs) compared to a nontransplanted comparison cohort. We identified all first-time RTRs in Denmark during 1990-2015 in a nationwide nephrology register...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32565
更新日期:2020-05-01 00:00:00
abstract::We used a cross-sectional survey to examine short-term anxiety and distress in women receiving different results following routine human papillomavirus (HPV) primary testing at cervical screening. Participants were women aged 24-65 (n = 1,127) who had attended screening at one of five sites piloting HPV primary screen...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32540
更新日期:2020-04-15 00:00:00
abstract::In colorectal cancer (CRC), hepatic arterial infusion (HAI) chemotherapy may convert primarily unresectable CRC liver metastases (CLM) into resectability, although the risk of metastatic recurrence remains high after CLM ablation. We investigated the role of antitumour immunity invoked by first-line oxaliplatin-HAI fo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32847
更新日期:2020-04-01 00:00:00
abstract::Results of epidemiologic studies of physical activity and ovarian cancer risk are inconsistent. Few have attempted to measure physical activity over the lifetime or in specific age windows, which may better capture etiologically relevant exposures. We examined participation in moderate-to-vigorous recreational physica...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32513
更新日期:2020-04-01 00:00:00
abstract::Long noncoding RNAs (lncRNAs) are involved in the pathology of colorectal cancer (CRC). Current efforts to eradicate CRC predominantly focused on targeting the proliferation of rapidly growing cancer epithelial cells. This is largely ineffective with resistance arising in most tumors after exposure to chemotherapy. De...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32608
更新日期:2020-03-15 00:00:00
abstract::Using a method optimized in hepatocellular carcinoma (HCC), we established patient-derived xenograft (PDX) models with an increased take rate (42.2%) and demonstrated that FBS +10% dimethyl sulfoxide exhibited the highest tumor take rate efficacy. Among 254 HCC patients, 103 stably transplantable xenograft lines that ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32564
更新日期:2020-03-15 00:00:00
abstract::G protein-coupled estrogen receptor-1 (GPER), a member of the G protein-coupled receptor (GPCR) superfamily, mediates estrogen-induced proliferation of normal and malignant breast epithelial cells. However, its role in breast cancer stem cells (BCSCs) remains unclear. Here we showed greater expression of GPER in BCSCs...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32588
更新日期:2020-03-15 00:00:00
abstract::Galunisertib (LY2157299), a promising small-molecule inhibitor of the transforming growth factor-beta (TGF-β) receptor, is currently in mono- and combination therapy trials for various cancers including glioblastoma, hepatocellular carcinoma and breast cancer. Using genetically modified mouse models, we investigated t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32568
更新日期:2020-03-15 00:00:00
abstract::More than two-thirds of patients with hepatocellular carcinoma (HCC) cannot receive curative therapy and have poor survival due to late diagnosis and few prognostic directions. In our study, nontargeted and targeted metabolomics analyses were conducted by liquid chromatography-mass spectrometry to characterize metabol...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32599
更新日期:2020-03-15 00:00:00
abstract::Breast cancer is the leading cancer diagnosis and second most common cause of cancer deaths in sub-Saharan Africa (SSA). Yet, there are few population-level survival data from Africa and none on the survival differences by stage at diagnosis. Here, we estimate breast cancer survival within SSA by area, stage and count...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32406
更新日期:2020-03-01 00:00:00
abstract::Acquired chemoresistance is a critical issue for advanced bladder cancer patients during long-term treatment. Recent studies reveal that a fraction of tumor cells with enhanced tumor-initiating potential, or cancer stem-like cells (CSCs), may particularly contribute to acquired chemoresistance and recurrence. Thus, CS...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32505
更新日期:2020-02-15 00:00:00
abstract::Over 10% of children with Wilms tumor (WT) have an underlying cancer predisposition syndrome (CPS). Cognizant of increasing demand for genetic evaluation and limited resources across health care settings, there is an urgent need to rationalize genetic referrals for this population. The McGill Interactive Pediatric Onc...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.32561
更新日期:2020-02-15 00:00:00
abstract::Bromodomain and extraterminal domain (BET) inhibitors are broadly active against distinct types of cancer, including nonsmall cell lung cancer (NSCLC). Previous studies have addressed the effect of BET-inhibiting drugs on the expression of oncogenes such as c-Myc, but DNA damage repair pathways have also been reported...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32515
更新日期:2020-02-15 00:00:00
abstract::The prevalence and clinical relevance of TP53 germline mutations in a large unselected breast cancer series are largely unknown. Here, we determined TP53 germline mutations in a large cohort of 10,053 unselected breast cancer patients through multigene panel-based next-generation and/or Sanger sequencing assays. We fo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32424
更新日期:2020-01-15 00:00:00
abstract::Patients with idiopathic pulmonary fibrosis (IPF) have higher risk of developing lung cancer, for example, squamous cell carcinoma (SCC), and show poor prognosis, while the molecular basis has not been fully investigated. Here we conducted DNA methylome analysis of lung SCC using 20 SCC samples with/without IPF, and n...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32532
更新日期:2020-01-15 00:00:00
abstract::The absolute risk reduction by prophylaxis in chemotherapy-induced febrile neutropenia (FN) is largest in patients at highest underlying risk. Therefore, reliable predictive models are needed. Here, we develop and validate such a model for risk of FN during chemotherapy cycles 2-6. A prediction score for risk of FN du...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32249
更新日期:2020-01-15 00:00:00
abstract::Melanoma of unknown primary (MUP) may have a different biology to melanoma of known primary, but clinical trials of novel therapies (e.g., immune checkpoint or BRAF/MEK inhibitors) have not reported the outcomes in this population. We therefore evaluated the overall survival (OS) among patients with MUP in the era of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32229
更新日期:2020-01-01 00:00:00
abstract::Previous studies have reported an association between hot tea drinking and risk of esophageal cancer, but no study has examined this association using prospectively and objectively measured tea drinking temperature. We examined the association of tea drinking temperature, measured both objectively and subjectively at ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32220
更新日期:2020-01-01 00:00:00
abstract::Combining the specificity of tumor-targeting bacteria with the sensitivity of biomarker detection would create a screening method able to detect small tumors and metastases. To create this system, we genetically modified an attenuated strain of Salmonella enterica to release a recombinant fluorescent biomarker (or flu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32414
更新日期:2020-01-01 00:00:00
abstract::Therapies targeted to human epidermal growth factor receptor 2 (HER2) have proven effective against tumors positive for HER2 amplification, but there is an unmet clinical need for the treatment of tumors that express HER2 protein in the absence of HER2 amplification. [fam-] trastuzumab deruxtecan (DS-8201a) is a novel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32408
更新日期:2019-12-15 00:00:00
abstract::Cancers occurring at the gastroesophageal junction (GEJ) are classified as predominantly esophageal or gastric, which is often difficult to decipher. We hypothesized that the transcriptomic profile might reveal molecular subgroups which could help to define the tumor origin and behavior beyond anatomical location. The...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32384
更新日期:2019-12-15 00:00:00
abstract::The impact of variations in serum thyroid hormone concentration within the euthyroid range on breast cancer risk remains unclear. We investigated the effect of serum thyrotropin (TSH) and thyroid hormone concentration on breast cancer risk. This cohort study involved 62,546 Korean women, aged ≥40 years, who were free ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32283
更新日期:2019-12-15 00:00:00
abstract::Akt is a promising therapeutic target for cancer treatment. In our study, we have identified that 7-deoxynarciclasine (7-DONCS) is a potential inhibitor of Akt, which results in the repression of multiple oncogenic processes in hepatocellular carcinoma (HCC). We have found that 7-DONCS suppresses the growth of HCC by ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32395
更新日期:2019-12-15 00:00:00
abstract::Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare NETs originating from the liver. These tumors are associated with heterogeneous prognosis, and few treatment targets for PHNETs have been identified. Because the major genetic alterations in PHNET are still largely unknown, we performed whole-exome sequ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32334
更新日期:2019-12-01 00:00:00
abstract::Fatty acids play a key role in cellular bioenergetics, membrane biosynthesis and intracellular signaling processes and thus may be involved in cancer development and progression. In the present study, we comprehensively assessed associations of 14,522 common single-nucleotide polymorphisms (SNPs) in 149 genes of the f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32194
更新日期:2019-11-15 00:00:00
abstract::Overuse of antibiotic drugs alters the composition of gut microbiota and has detrimental effects on the host. In our study, we investigated association of gut flora and antibiotics in the prognosis of patients with liver cancer who have undergone chemotherapy by analyzing two independent clinical studies. We retrospec...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32339
更新日期:2019-11-15 00:00:00
abstract::We analyzed the number of circulating tumor cells (CTCs) and Epstein-Barr virus DNA (EBV DNA) for diagnosis, monitoring and prognosis of patients with metastatic nasopharyngeal carcinoma (mNPC). The levels of CTCs and EBV DNA were measured at baseline and after first-line chemotherapy in 148 mNPC patients prospectivel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32380
更新日期:2019-11-15 00:00:00
abstract::High-grade serous epithelial ovarian cancer (HGS-EOC) is a systemic disease, with marked intra and interpatient tumor heterogeneity. The issue of spatial and temporal heterogeneity has long been overlooked, hampering the possibility to identify those genomic alterations that persist, before and after therapy, in the g...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32288
更新日期:2019-11-15 00:00:00
abstract::Benzene is considered a carcinogen, mostly based on evidence of causality for myeloid leukemia from high levels of exposure in occupational studies. We used United States Environmental Protection Agency National Ambient Toxics Assessment (NATA) estimates of low-level ambient benzene to examine potential associations f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32202
更新日期:2019-11-15 00:00:00
abstract::In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were ana...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32361
更新日期:2019-11-15 00:00:00
abstract::JNK activity has been implicated in the malignant proliferation, invasion and drug-resistance of glioma cells (GCs), but the molecular mechanisms underlying JNK activation are currently unknown. Here, we reported that MKK7, not MKK4, directly activates JNK in GCs and exerts oncogenic effects on tumor formation. Notabl...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32321
更新日期:2019-11-01 00:00:00
abstract::The Raf murine sarcoma viral oncogene homolog B (BRAFV600E ) mutation (MT) in metastatic colorectal cancer (CRC) is a well-known prognostic indicator and a negative predictive biomarker for antiepidermal growth factor receptor (EGFR) treatment. However, the clinical characteristics and significance of BRAFnon-V600E MT...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32320
更新日期:2019-11-01 00:00:00
abstract::Improved biomarkers for prostate cancer (PC) risk stratification are urgently needed. Here, we aimed to develop a novel multimarker model for prediction of biochemical recurrence (BCR) after curatively intended radical prostatectomy (RP), based on minimally invasive sampling of blood and urine. We initially measured t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32296
更新日期:2019-11-01 00:00:00
abstract::Claudin7 (cld7) is a cancer-initiating cell (CIC) marker in gastrointestinal tumors, a cld7-knockdown (kd) being accompanied by loss of tumor progression. Tumor exosomes (TEX) restoring CIC activities, we explored the contribution of cld7. This became particularly interesting, as tight junction (TJ)- and glycolipid-en...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32312
更新日期:2019-10-15 00:00:00
abstract::Caspase recruitment domain-containing protein 9 (CARD9) is an adaptor protein and highly expressed in myeloid cells. Our previous study demonstrates a critical protective effect of CARD9 in the development of colitis-associated colon cancer. Nevertheless, the effect of CARD9 in lung cancer remains unclear. Here, using...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32355
更新日期:2019-10-15 00:00:00
abstract::Malignant mesothelioma (MM) is a highly aggressive form of cancer with limited treatment options. Although the role of NK cells has been studied in many solid tumors, the pattern of NK-cell subsets and their recognition of mesothelioma cells remain to be explored. We used RNA expression data of MM biopsies derived fro...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32363
更新日期:2019-10-15 00:00:00
abstract::Oxaliplatin, which is widely used as chemotherapy for certain solid cancers, frequently causes peripheral neuropathy. Commonly described neuropathic symptoms include aberrant sensations such as mechanical allodynia (hypersensitivity to normally innocuous stimuli). Although oxaliplatin neuropathy is a dose-limiting tox...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32043
更新日期:2019-10-15 00:00:00
abstract::As the most abundant noncoding RNA in cells, tRNA plays an important role in tumorigenesis and development. The report of tRNA on the pathogenesis of lung adenocarcinoma is rare. It is of great clinical significance to explore the relationship between tRNA expression and prognosis of lung adenocarcinoma. The expressio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32250
更新日期:2019-10-01 00:00:00